DISC ONE
Episodes (with Play All function)
- No Meals on Wheels (21:23)
- Boys Do Cry (22:44)
- No Chris Left Behind (22:10)
- It Takes a Village Idiot, and I Married One (23:00)
- Meet the Quagmires (21:58)
Audio commentary on "No Meals on Wheels" by executive producer Seth MacFarlane, writer/actor Mike Henry, director Greg Colton, actor Patrick Warburton, and composer Walter Murphy
Audio commentary on "Boys Do Cry" by executive producer Seth MacFarlane, co-executive producer Danny Smith, writer Cherry Chevapravatdumrong, and director Brian Iles
Audio commentary on "No Chris Left Behind by executive producers Seth MacFarlane, David A. Goodman and Chris Sheridan, writer Patrick Meighan, director Pete Michels and actor Seth Green
Audio commentary on "It Takes a Village Idiot, and I Married One" by executive producers Seth MacFarlane, co-executive producer Danny Smith, writer/actor Alex Borstein and actor Mila Kunis
Audio commentary by co-executive producer Danny Smith, producer Kara Vallow, writer Mark Hentemann, director Dan Povenmire and actor Adam Carolla
Original Televised Episodes
- No Meals on Wheels (21:26)
- Boys Do Cry (21:54)
- No Chris Left Behind (21:39)
- It Takes a Village Idiot, and I Married One (21:51)
- Meet the Quagmires (21:48)
Start-up promo for "Family Guy" (0:22)

DISC TWO
Episodes (with Play All function)
- Movin' Out (Brian's Song) (21:49)
- Believe It or Not, Joe's Walking on Air (22:15)
- Stewie Kills Lois (23:18)
- Lois Kills Stewie (26:11)
- Padre de Familia (23:56)
- Peter's Daughter (22:28)
Audio commentary on "Movin' Out (Brian's Song)" by executive producers Seth MacFarlane, David A. Goodman and Chris Sheridan, writer John Viener and director Cyndi Tang
Audio commentary on "Believe It or Not, Joe's Walking on Air" by executive producer Seth MacFarlane, writer Andrew Goldberg, director Julius Wu, actor Patrick Warburton and composer Walter Murphy
Audio commentary on "Stewie Kills Lois" by executive producer Seth MacFarlane, executive producer/writer David A. Goodman, executive producer Chris Sheridan, co-executive producer Steve Callaghan, director John Holmquist, actors Alex Borstein and Seth Green and composer Ron Jones
Audio commentary on "Lois Kills Stewie" by executive producers Seth MacFarlane, David A. Goodman and Chris Sheridan, associate producer Kim Fertman, writer Steven Callaghan, director Greg Colton, actor Alex Borstein and composer Ron Jones
Audio commentary on "Padre de Familia" by executive producers Seth MacFarlane and David A. Goodman, writer Kirk Buler, director Pete Michels and actor Phyllis Duller
Audio commentary on "Peter's Daughter" by executive producers Seth MacFarlane and David A. Goodman, executive producer/writer Chris Sheridan and actor Mila Kunis
Original Televised Episodes
- Movin' Out (Brian's Song) (21:04)
- Believe It or Not, Joe's Walking on Air (21:27)
- Stewie Kills Lois (21:11)
- Lois Kills Stewie (21:47)
- Padre de Familia (21:44)
- Peter's Daughter (21:53)

DISC THREE
Episode
- McStroke (23:27)
Audio commentary on "McStroke" by executive producers Seth macFarlane and David A. Goodman, writer Wellesley Wild, director Brian Ilse and actor Lisa Wilhoit
Original Televised Episode
- McStroke (21:45)
Deleted Scenes (with Play All function) (18:40)
- Autistic Comedian (0:19)
- Persian Guy (0:10)
- Corpse of River Phoenix (0:36)
- Lois and Hector (0:22)
- Disabled Family (0:20)
- North Koreans (0:20)
- Handicap Inaccessible (0:34)
- Brian Picks up Lois (0:11)
- Chris' Divorce (0:21)
- Native American Midgets (0:18)
- Quagmire re:Daniel Stern (0:23)
- Mr. Belvedere (0:07)
- Peter Laughs in a Meeting (0:36)
- Peter Writes to Phil Hartman (0:26)
- Black Inmate on Death Row (0:12)
- Tom Tucker/Brian Hits on Woman (0:42)
- Bad Santa (0:21)
- Tara Reid's Gynecologist (0:20)
- Women's Tennis (0:20)
- Peter with Dummy (0:09)
- Jokes About Joe's Legs (0:32)
- Texas Militiaman (0:29)
- Extreme!!! (0:26)
- Terrorists (0:14)
- Murder Reenactment (0:45)
- Crumbs in My Briefs (0:15)
- Benjamin Franklin (0:15)
- Manute Bol at KKK Meeting (0:16)
- Stewie Farts (0:08)
- MeisterBrau (0:22)
- Herbert and Joe (0:11)
- Stewie's Laws (0:11)
- Stewie's Laws 2 (0:10)
- Disabled Guy at Church (0:16)
- Bad Idea Hooker (0:33)
- Swedish Baker (0:13)
- Christian Missionary (0:18)
- NBA Analysis Show (0:24)
- Peter's Pledge of Allegiance (0:25)
- Brad & Angelina Pick Babies (0:12)
- House Roofing Contest (0:29)
- Carter Watches "Heroes" (0:10)
- Hip Hop Grills (0:40)
- Wisconsin Man (0:23)
- Neo-Nazi with Down's Syndrome (0:19)
- Pie Fight (1:13)
- Hot Women (0:10)
- Brian & Stewie Blame Cleveland (0:50)
- Meg's Wedding (0:19)
Animatic Episodes (with optional commentaries)
- "No Meals on Wheels" (23:34)
-- Audio commentary by Young Baek, Greg Colton, Deborah Cone, Monica Lee and Ron Smith
- "No Chris Left Behind" (22:10)
-- Audio commentary by Brent Crowe, Kip Noschese, Steve Fonti, Pete Michels and Karin Perrotta
- "McStroke" (23:09)
-- Audio commentary by Ed Acosta, Mark Covell, Brian Iles, Annie McMillan and Jeff Stewart
"Family Guy 100th Episode Special" (21:41)
"Family Guy Live!" at the Just for Laughs Comedy Festival, Montreal 7/21/2007 (71:27)
"Peter Shin Draws Lois" featurette (4:09)
"The Making of the 100th Episode" featurette (24:30)
"Favorite Scenes" featurette (11:34)
"I'm Huge (and the Babes Go Wild)" music video (2:49)

English HoH, French, Spanish

1.33:1

Non-Anamorphic

NTSC

English Dolby Digital 5.1

Special Case